Monofluoroacetate (know as Compound 1080) was originally developed and marketed as an insecticide. It functions primarily by interfering with the citrate step in the Krebs cycle . The Krebs cycle is the major and an essential mechanism by which all air breathing creatures utilize food to produce energy. It is therefore universally toxic to all […]
About Quinn. E. Whiting-Okeefe, BA, MA, MD, FACMI
Dr Whiting-OKeefe graduated from the University of Utah Sigma Cum Lauda and Phi Beta Kappa with dual Bachelor degrees in chemistry and mathematics. He then did PhD work in mathematics at the California Institute of Technology until he interrupted his dissertation work, accepting an MA in Mathematics, to go to medical school at the University of Utah. His pre-med undergraduate courses included: genetics, ecology, comparative anatomy and mammalogy. For the latter, he spent six months as a field research assistant studying mouse populations in Utah. He graduated from medical school second in his class in 1974 receiving the degree of Medical Doctor. He did a residency in internal medicine at the University of California, San Francisco (the life science campus), and was Board Certified in Internal Medicine in 1978.
At the time, much of clinical knowledge was based on studies similar in methodological structure to DoC’s research on aerial 1080. He recognized that this was an important problem for which his dual backgrounds in mathematics and medicine especially qualified him to address. In 1977 he applied and was accepted as Robert Wood Johnson (RWJ) Clinical Scholar specializing in biostatistics, statistical inference and research design, especially the connection between the structure of experiments, the statistics, and conclusions. As an RWJ Scholar, he published several papers on this and related subjects. Simultaneously, he did a fellowship in Rheumatology and was board certified in 1983.
In 1979, he joined the faculty at the University of California, San Francisco, with a dual appointment in Medicine and Medical Information Science. He rose to the rank of Associate Professor before going to work in the private sector developing clinical information systems. He attained the position of Vice President at three companies, including Senior Vice President of Engineering at Bell Atlantic Healthcare Systems, where he designed and lead the development of OACIS, a $50 million project.
Throughout his activities in medical informatics, he continued to design and analyze studies, it being his first real academic passion after mathematics. From 1995 to 1998, Dr. Whiting-OKeefe single-handedly developed the Healthcare Outcomes Performance System which uses advance hierarchical statistical linear modeling to predict healthcare outcomes. Since1998 when he retired and moved to New Zealand, Dr. Whiting-OKeefe has continued to design and analyze experiments and publish papers with his long time colleague and friend, David B Hellmann, M.D., Vice Dean and Aliki Perroti Professor of Medicine at Johns Hopkins University School of Medicine.
Dr Whiting-OKeefe proudly became a New Zealand citizen in 2002. He is 63 years old and lives with Patricia, his wife of 35 years and co-author, in Port Charles, Coromandel, New Zealand.